Miso Clinic · Clinical Reference Library

Clinical reference library — six injectables, three lifting devices

A reference for each of the six injectables and three lifting devices this clinic actually stocks and uses — not marketing copy, but what the material is, how it works, how far the evidence actually goes, and what not to expect from it. All written and reviewed by Dr. Lee Chi-Hak, in Korean and English.

Ten references · KO · EN Reviewed 2026 Miso Clinic, Daegu · Dr. Lee Chi-Hak 한국어판

Why hold this many

Ageing does not present as one problem. Volume loss and thinning of the skin itself have different causes, and within thinning, a face that has lost regenerative capacity is not the same as a face that has lost material.

Different problems need materials that work differently. A clinic holding one product will use that product on every face that walks in. That is why this clinic carries four classes across six products.

Injectables and devices do not work on the same tissue. An injectable supplies material to the dermis; a device puts heat into the layers beneath it. Heat applied to skin that has run out of material has little to contract; material added to a face whose structure has descended simply thickens what is already loose. Whether a clinic can plan the two together is, in practice, one of the more useful things to ask about.

Holding them and using them well are different things, though. So each reference separates what is evidence from what is expectation. The parts that rarely appear in promotional material — that a product cannot be reversed, that the evidence is thin, that this particular material will not fix your problem — are usually the parts that matter most in consultation.

Start from the complaint

Starting from a product name is the slow way round. Starting from what actually bothers you about your face right now is faster.

Where to start
If this is your situationRead first
You don't know where to beginSix boosters compared — which one fits
Coarse texture, makeup sitting badlyGOURI · Rejuran
Thinning skin with crepey fine linesRejuran
Skin feels hollow and low in densityRe2O · CellREDM
The concern is thin skin around the eyesCellREDM
Loss of firmness with gentle hollowingRadiesse · DCLASSY
Tendons and veins standing out on the handsRadiesse
You want to avoid particulate products over nodule riskGOURI · Rejuran
You would rather avoid human-derived materialGOURI · Rejuran · Radiesse · DCLASSY
The jawline has softened and the outline has droppedXERF · Density · Oligio Kiss
You are looking at devices rather than injectionsXERF · Density
You cannot tell radiofrequency from ultrasoundOligio Kiss
You wonder whether you need both an injectable and a deviceSix boosters compared · XERF

Most people match several rows at once. Deciding which problem dominates is most of what a consultation is for.

The references

Injectables first, ordered by class, then the lifting devices. Each reference covers one item in full, and the Korean and English editions carry the same content.

Injectables — comparison

Comparison
Six collagen boosters compared Starts from volume versus density, separates the four classes — PCL, PN, hADM, CaHA — and works through to which product fits which complaint. Begin here if this is new to you. · KO

Liquid PCL

PCL
GOURI A 100% liquid PCL with no particles. How that differs from particulate PCL, and why it addresses skin quality rather than volume. · KO

PN (polynucleotide)

PN
Rejuran HB PLUS What polynucleotide from salmon DNA actually is, how Healer, HB and HB PLUS differ, and six reasons people report that it did nothing. · KO

hADM (human acellular dermal matrix)

hADM
Re2O Supplying the material instead of signalling for it. Where the raw material comes from and what processing it goes through, stated plainly. · KO
CellREDM The same hADM milled to roughly 75 μm. What smaller particles change about where the product can be used. · KO

CaHA (calcium hydroxylapatite)

CaHA
Radiesse The best-evidenced of the six. What is approved in Korea versus the United States, and the dorsal hand indication. · KO
DCLASSY CaHA The three-stage action of CaHA, and how the fact that it cannot be dissolved out governs every decision about placing it. · KO

Lifting devices

From here on these are not injections but devices that work by heat. For all three, no clinical trial of the device itself is publicly available, and each reference keeps class-level evidence and device-level evidence clearly apart.

Lifting devices
XERF Monopolar radiofrequency from Lutronic. Two frequencies, four handpiece sizes and how they are chosen — and why an advertising pre-review number is not an approval number. · KO
Density Radiofrequency from Jeisys Medical. What delivering monopolar and bipolar energy in sequence actually changes, and why with a heat device the real risk is a burn. · KO
Oligio Kiss Wontech's combined radiofrequency and focused ultrasound platform, approved in Korea as The Great RF Sonata. Warming a volume versus placing discrete points, and how it differs from Oligio and Oligio X. · KO

How to read these

  • They have an author. All are written and reviewed by Dr. Lee Chi-Hak, with the authoring clinic named at the foot of each page
  • Prices are not listed. Korean medical advertising rules govern how treatment fees may be published; we give exact figures at consultation
  • Limits of the evidence are stated alongside it. Where studies are small or long-term data absent, we say so. Unverified figures are left out rather than repeated
  • We do not rank products against each other. For most of these pairings no head-to-head study exists, so there would be no basis for it
  • Device references name the owner of the evidence. Class-level findings are never presented as if they were a study of the particular device
  • They do not replace assessment. The same complaint can have different causes and therefore different answers. Read first, then decide together in consultation

About the authoring clinic

This library was written and reviewed by Dr. Lee Chi-Hak, director of Miso Clinic in Daegu, South Korea. The clinic stocks six collagen boosters and skin boosters with genuinely different active materials — liquid PCL (GOURI), PN (Rejuran), hADM (Re2O, CellREDM) and CaHA (Radiesse, DCLASSY) — along with three lifting devices (XERF, Density, Oligio Kiss), and selects between them according to which kind of ageing the face is actually showing. The clinic's stated approach is restraint: results that are not obviously treatments, and the judgement to do less where less is right.

Miso Clinic
DirectorDr. Lee Chi-Hak
Address4F Bombom Building, 125 Dongdeok-ro, Jung-gu, Daegu, South Korea · Exit 1, Kyungpook National University Hospital Station
Telephone+82 53-428-2700
KakaoTalkMiso Clinic channel
HoursWeekdays 11:00–19:00 (lunch 13:00–14:00) / Saturday 10:00–16:00 (no lunch break) / Closed Sundays and public holidays
Websiteclinicmiso.co.kr
한국어진료 자료실 (Korean)

Every document in this library provides general information about aesthetic treatments and does not substitute for medical diagnosis or care. Outcomes and adverse effects vary with individual skin condition, age and underlying illness, and no result is guaranteed. Decisions about treatment should be made in an in-person consultation with a qualified clinician.

← Miso Clinic home