Miso Clinic · Clinical reference

BYRYZN: the one booster that adds water rather than asking the skin to build

The other six boosters we keep at Miso Clinic all work by making the skin build something or by replacing a material it has lost. BYRYZN does neither. It places a water-binding gel directly into the dermis. That changes what you should expect — and it gives this product one property none of the others have: it can be undone.

Clinical reference About a 9-minute read Reviewed 2026 Miso Clinic, Daegu · Lee Chi-Hak, MD 한국어 자료

In one sentence

BYRYZN Skinbooster HA is a cross-linked hyaluronic acid gel with lidocaine, injected in small deposits into the dermis so that the skin holds water for a sustained period. Stimulating collagen is not its primary mechanism.

At a glance

BYRYZN Skinbooster HA
Class	Cross-linked hyaluronic acid (HA)
Brand · distribution	Hugel
Manufacturer	ACROSS Co., Ltd. — an affiliate of Hugel, not Hugel itself
Composition	Cross-linked HA gel with 0.3% lidocaine (carton states two 1.1 mL syringes)
Korean regulatory status	Medical device (tissue-restoration biomaterial). Stated indication: temporary improvement of facial wrinkles in adults
Reversible	Yes — the only class here that hyaluronidase can dissolve
Published trial	Yes, but a single-arm pilot study in 20 people followed for 12 weeks
What it targets	Texture, fine lines, hydration. It is not a volumising or lifting treatment

About the long number. Numbers such as 62026-I10-23-2790, common on Korean clinic pages, are advertising pre-review numbers, not MFDS product licence numbers. We could not verify a licence number for BYRYZN in public sources, so this page does not state one.

What cross-linking actually changes

Hyaluronic acid already exists in your dermis. Its job is to bind many times its own weight in water, and the amount present falls with age.

The problem with simply injecting it is that the body breaks it down within days — hyaluronidase is always circulating. That is why conventional “skin hydration” injections have to be repeated often.

Cross-linking bonds the chains into a mesh. A mesh is harder for the enzyme to cut apart, so it persists longer. BYRYZN is cross-linked, and the manufacturer describes the degree of cross-linking as deliberately low to keep the gel soft.

Non-cross-linked versus cross-linked
	Non-cross-linked	Cross-linked (BYRYZN)
Breakdown	Fast	Slower
Interval	Short, repeated often	Comparatively longer
Consistency	Watery	A gel that holds some shape
Trade-off	May feel short-lived	Placed too superficially, it can show or clump

Lasting longer is not purely an advantage. It also means that a poor placement lasts longer. With this product, the depth of injection matters more than the volume.

It can be undone

Of the seven products in our clinical reference library, only BYRYZN can be dissolved.

Hyaluronidase breaks hyaluronic acid down; injected into the area, most of the product disappears within hours to days. If it clumps, shows through the skin, or simply sits in the wrong place, that is recoverable.

No other class here offers this. Hyaluronidase has no effect on the CaHA in DCLASSY and Radiesse, and no dissolving agent for CaHA exists. The same applies to the PCL in GOURI, the PN in Rejuran, and the hADM in Re2O and CellRedM — once placed, you wait.

This matters most if you have never had a booster before. Starting with a material you can reverse is a reasonable way to find out how your skin responds.

Not a free pass. Hyaluronidase can itself provoke an allergic reaction, and it also degrades the native hyaluronic acid around the injection site. “We can dissolve it” is a safety net for when something goes wrong — not a licence to inject carelessly.

How it differs from the other six

The first thing to separate when choosing a booster is not the brand name but what kind of material it is.

What each class does
Class	Product	Mechanism	Reversible
Cross-linked HA	BYRYZN	Places a water-binding material directly	Yes
Liquid PCL	GOURI	Spreads through the dermis and induces collagen	No
PN	Rejuran	Improves the skin’s own regenerative environment	No
hADM	Re2O · CellRedM	Replenishes extracellular matrix components	No
CaHA	Radiesse · DCLASSY	Adds volume while stimulating collagen	No

Read the table a different way: with the other four classes, your skin has to do the work. Building collagen, using a better regenerative environment, incorporating replacement material — all of that takes weeks. BYRYZN skips that step. The material binds water as soon as it is in place.

The cost is that the skin itself has not changed. When the gel breaks down, you return to where you started. That is this product’s real limitation, and the reason it is often planned alongside another class rather than instead of one.

Who it suits, and who it does not

A reasonable choice if

Rough texture with a tight, dehydrated feel is your main complaint
You have been having hydration injections but they do not last long enough to keep returning
This is your first booster and you would rather start with something reversible
You are bothered by shallow lines from habit — sleep lines, neck lines
You are already on another class of booster and want hydration addressed in the meantime

Not the right tool if

Sagging is the main problem — no injection lifts. Energy devices such as XERF, Density or Oligio Kiss address that layer
There is significant volume loss — booster volumes are not designed to fill
Your goal is to make the skin structurally thicker — a collagen-inducing class fits better
There is active infection or inflammation at the site — we wait until it settles
You have had a reaction to a hyaluronic acid product before, or are allergic to lidocaine
You are pregnant or breastfeeding — there is no data in this population

How far the evidence actually goes

Among the seven boosters we keep, few have a published trial carried out on the product itself. BYRYZN is one of the few that does. That is not the same as the evidence being strong, so we separate what has been shown from what has not.

What has been shown

A team at Yonsei University’s Severance Hospital published a study in Journal of Cosmetic Dermatology in 2024. The product is named in the paper, so it can be cited as evidence for this product rather than for the class in general.

Lee et al., J Cosmet Dermatol 2024
Design	Prospective, single-centre, single-arm pilot study (the authors describe it as a pilot)
Participants	20 people aged 30–60, mean age 54.1
Protocol	Three intradermal sessions two weeks apart, followed for 12 weeks
Wrinkles	Lemperle scale 2.60±0.60 → 1.55±0.51 at week 8 (about a 40% reduction), holding at roughly 33% at week 12
Other measures	Roughness, elasticity, pore size, hydration and gloss all improved significantly
Safety	No serious adverse events. One participant developed a transient subcutaneous nodule

What has not been shown

There was no control group. Nothing was compared against untreated skin, so this study alone cannot separate the product’s effect from everything else
Twenty people is too few to detect uncommon adverse events
Follow-up stopped at 12 weeks. What happens afterwards is not in this study, which is why this page does not claim a duration in months
Mean age was 54.1 — a narrow band of the population
The HA concentration and the cross-linking agent are not stated in any source we could verify. The manufacturer’s claims of “minimal cross-linking” and “reduced Tyndall effect” are company statements without independent verification
No study has compared BYRYZN head to head with another skin booster, so this page does not rank products

What the appointment involves

ConsultIdentifying the main problemWhether texture and hydration are the issue, or whether sagging and volume loss are also present, decides whether this product is the right one. We also review medications, previous fillers and boosters, and allergies.
PrepCleansing and topical anaestheticLidocaine is in the product, but depending on the area we apply numbing cream for 20–30 minutes first.
InjectionSmall deposits, superficially placedRather than concentrating product in one place, it is distributed across many points. Since depth determines the result here, this is the step that matters.
AfterCooling and aftercareInjection marks and some swelling remain. We go through same-day care before you leave.

On the number of sessions. The published study used three sessions two weeks apart. That is not evidence that everyone needs three. It depends on skin condition and goal, and we decide it in consultation.

Timeline — when you see it

Same dayInjection marks and swellingSmall raised points where product was placed. These usually settle within a day or two.
2–3 daysMarks subsideAny bruising begins to fade from around this point.
1–2 weeksHydration and textureUnlike the other classes, change tends to be noticeable early, because the material binds water immediately.
Week 8The study’s best pointWrinkle scores were most improved at week 8 in the published trial.
Week 12Where the study endedMuch of the week-8 improvement was still present. Beyond this point there is no published data.

Downtime and aftercare

Injection marks, swelling and bruising are common. They usually settle within a few days, but if you have something important that day, move the appointment.

On the day, avoid saunas, hot baths, strenuous exercise and alcohol, and do not rub the treated area.

The Tyndall effect. Hyaluronic acid placed too superficially can make the area look faintly bluish, because light scatters in the gel. Thin skin, such as under the eyes, shows it most readily. The manufacturer says this product is designed to reduce it, but no independent data supports that claim. In practice the variable is depth, not brand — and if it does happen, this is the one class that can be dissolved.

Call us immediately if. Severe pain at the moment of injection, skin turning white or dusky, or any change in vision can — rarely — signal a vascular complication. Time matters, so do not wait to see if it settles. Redness, swelling or heat appearing days later also needs to be seen.

Frequently asked questions

How is this different from a standard hydration injection?

The ingredient is the same hyaluronic acid; what differs is cross-linking. Conventional hydration injections use non-cross-linked HA, which the body's enzymes break down quickly, so treatments have to be repeated at short intervals. BYRYZN is cross-linked into a mesh, which resists that breakdown for longer. The trade-off is that a poorly placed injection also lasts longer, which makes depth of placement more important.

Can it really be dissolved?

Yes. Injecting hyaluronidase breaks hyaluronic acid down. Of the seven boosters we keep, this is the only reversible one. Hyaluronidase has no effect on CaHA products such as Radiesse and DCLASSY, for which no dissolving agent exists, and GOURI, Rejuran, Re2O and CellRedM all have to be waited out. That said, hyaluronidase can itself cause allergic reactions and degrades the native hyaluronic acid nearby, so it is best understood as a safety net rather than a routine option.

How long does it last?

What has actually been shown is 12 weeks. Much of the improvement was still present at that point, and no data has been published beyond it. Figures such as 'lasts several months' circulate online without a traceable source, so we do not repeat them. Cross-linked HA persisting longer than non-cross-linked is a well-established property of the class; a specific number of months depends on the area and the individual.

How is it different from Rejuran?

They do different jobs. The PN in Rejuran improves the skin's own regenerative environment, which means the skin has to respond and that takes weeks. BYRYZN places a water-binding material directly, so change appears early, but when the material breaks down the skin returns to its previous state. If the concern is skin that has genuinely become thin and reactive, Rejuran fits; if the concern is texture and hydration on a shorter horizon, BYRYZN fits. They are not competitors so much as products used in sequence or together.

How many sessions do I need?

The published study used three sessions at two-week intervals. That is not evidence that three is the required number for everyone. It depends on skin condition and goal, and we decide it in consultation. We prefer to treat once, see how the skin responds, and adjust from there rather than committing to a package up front.

Does it hurt?

The product contains 0.3% lidocaine, so discomfort decreases as the treatment proceeds. It is still a series of superficial dermal injections, so some stinging is unavoidable. Depending on the area we apply numbing cream beforehand. Tell us before treatment if you have ever reacted to lidocaine.

I have heard the skin can look bluish afterwards.

That is the Tyndall effect, which occurs when hyaluronic acid is placed too superficially and light scatters within the gel. It shows most easily where skin is thin, such as under the eyes. The manufacturer states this product is designed to minimise it, but there is no independent verification of that claim. What actually determines it is injection depth rather than the brand, and if it does occur, this class can be reversed with hyaluronidase.

What does it cost?

It depends on the volume used, the area treated and whether it is combined with other treatments. Korean medical advertising rules govern how treatment prices may be published, so we do not list them here and instead give you exact figures at consultation.

Who wrote this

This reference was written and reviewed by Lee Chi-Hak, MD, medical director of Miso Clinic in Daegu, South Korea. The clinic keeps seven collagen and skin boosters with genuinely different mechanisms — cross-linked HA (BYRYZN), liquid PCL (GOURI), PN (Rejuran), hADM (Re2O and CellRedM) and CaHA (Radiesse and DCLASSY) — alongside three lifting devices, and selects among them according to what kind of ageing the face is actually showing. Our approach is restraint: choosing to do less is also a clinical decision.

Miso Clinic
Medical director	Lee Chi-Hak, MD
Address	4F Bombom Building, 125 Dongdeok-ro, Jung-gu, Daegu, South Korea · Exit 1, Kyungpook National University Hospital Station
Phone	+82-53-428-2700
KakaoTalk	Miso Clinic channel
Hours	Weekdays 11:00–19:00 (lunch 13:00–14:00) / Saturday 10:00–16:00 (no lunch break) / Closed Sundays and public holidays
Reference library	All booster and device references
Column	Eight things to tell your doctor
한국어	바이리즌 가교 히알루론산 스킨부스터 (Korean)

References

Lee JH, Kim J, Lee YN, Choi S, Lee YI, Suk J, Lee JH. The efficacy of intradermal hyaluronic acid filler as a skin quality booster: A prospective, single-center, single-arm pilot study. J Cosmet Dermatol. 2024;23(2):409–416. doi:10.1111/jocd.15944 — the source of every figure cited on this page. As the authors state, it is an uncontrolled pilot study in 20 people followed for 12 weeks.
BYRYZN product information (byryzn.co.kr) — the source for cross-linked hyaluronic acid with lidocaine, the medical-device (tissue-restoration biomaterial) classification, and the stated indication of temporary improvement of facial wrinkles in adults. The number 62026-I10-23-2790 shown there is an advertising pre-review number, not a product licence number.
Product carton — cross-linked hyaluronic acid, 0.3% lidocaine, two 1.1 mL syringes.
Manufacturer — the paper names ACROSS Co., Ltd. (Gangwon-do, Korea) as manufacturer; ACROSS is reported as an affiliate of Hugel.

Deliberately absent. HA concentration, the cross-linking agent and its degree, a duration in months, and any ranking against other skin boosters — each either could not be verified in a primary source or has never been studied comparatively. We do not publish figures we cannot verify.

This reference provides general information about a cosmetic procedure and does not replace medical diagnosis or treatment. Results and side effects vary with skin condition, age and underlying health, and no outcome is guaranteed. Any decision to proceed should be made in an in-person consultation with a physician.

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