Re2O and Rejuran — they place different things
Re2O (hADM) places the material the dermis is built from, directly. Rejuran (PN) places no such material — it changes the environment the dermis recovers in. Both target dermal density and texture, and neither answers for lost volume.
In short
Re2O and Rejuran place different things. Re2O (hADM) places the material the dermis is built from, directly. Rejuran (PN) places no such material — it changes the environment the dermis recovers in. Both target dermal density and texture, and neither answers for lost volume.
Side by side
| Re2O (hADM) | Rejuran (PN) | |
|---|---|---|
| Material | Human acellular dermal matrix | Polynucleotide |
| Nature | A tissue-derived matrix of collagen, elastin and more | A single long-chain polymer |
| Form | Lyophilised powder, mixed before placement | Aqueous injectable from the start |
| After placement | It settles in the dermis | It works as it degrades |
| Plane | Dermis | Dermis |
| Mainly aims at | Dermal support | Recovery environment · texture |
| Reversal injection | Not applicable | Not applicable (degradable) |
Adding material, or changing the environment
What separates them is how each behaves once it is in.
- Re2O settles. A matrix of collagen and elastin remains in the dermis as supporting structure. Material is added directly.
- Rejuran works as it degrades. It forms a water-holding mesh that changes the recovery environment, and disappears in the process.
- So the session design differs. Re2O carries a lighter session burden; Rejuran is built up as a course of three to four sessions, three to four weeks apart.
What follows from a human-derived material
That Re2O comes from donated human tissue shows up directly in how it is handled.
- Traceability is close. Donation, processing, testing, storage and distribution are all recorded.
- It uses the body’s own building materials — a different starting point from a synthetic polymer.
Rejuran is the opposite character: a single material held to a specification. Which of those you prefer is itself one axis of the choice.
Choosing between them
| If this is the goal | The side that fits |
|---|---|
| A thinned dermis that needs support | Re2O — material added directly |
| Fewer sessions | Re2O |
| Thin, reactive skin | Rejuran — a degradable material is a lighter start |
| A first booster | Rejuran |
| A preference for human-derived material | Re2O |
| Lost volume | Neither — that is a filling material |
| Both apply | They place different things, so we separate them in time |
We do not rank them. Products that place different things cannot be put in a single line.
Can they be combined
Yes. They place different things, so they do not substitute for each other. But we separate them in time — on the same day, a reaction could not be attributed to either.
We place one, review the skin, and then decide the combination and the order. The class as a whole is compared in collagen boosters compared; the products are on the Re2O and Rejuran pages.
Frequently asked questions
Which of Re2O and Rejuran suits my skin?
They place different things. If a thinned dermis needs support, Re2O; if the skin is thin and reactive, or this is a first booster, Rejuran. Both target dermal density and texture.
Re2O is newer — does that make it better?
Launch date and fit are separate questions. The two place different things and work in different ways, so we do not rank them — in consultation we start from what has been lost.
Can they be combined?
Yes. They place different things, so they do not substitute for each other. But we separate them in time — on the same day a reaction could not be attributed to either. We place one, review the skin, then decide.
How do the sessions differ?
Re2O settles, so the session burden is lighter. Rejuran is built up over a course — we run three to four sessions, three to four weeks apart.
Can either be dissolved?
Neither dissolves with hyaluronidase, because neither is hyaluronic acid. Both are nonetheless degraded by the body, so neither stays in place indefinitely.
Will either restore lost volume?
Neither is a filling product. Both target dermal density and texture. If lost volume is the main concern, that is a filling material.
Which should come first?
Whichever has fallen further. If support is the larger problem, Re2O first; if texture and reactivity are, Rejuran first. Then we review the skin and decide the next step.
Who wrote this
Written and reviewed by Lee Chi-Hak, MD, director of Miso Clinic, Daegu. The treatment standards and injection design here are the ones we use in practice.
| Medical director | Lee Chi-Hak, MD |
|---|---|
| Address | 4F Bombom Building, 125 Dongdeok-ro, Jung-gu, Daegu, South Korea · Exit 1, Kyungpook National University Hospital Station |
| Phone | +82-53-428-2700 |
| Hours | Weekdays 11:00–19:00 (lunch 13:00–14:00) / Saturday 10:00–16:00 (no lunch break) / Closed Sundays and public holidays |
| Columns | All clinical columns |
| Reference library | All booster and device references |
This is general medical information and does not replace consultation. Indications, method and whether to treat at all should be decided after examination.
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