CellRedM · Re2O and Rejuran — they place different things
The difference between the two classes is what actually goes in. hADM places the material the dermis is built from, directly. PN places no such material — it changes the environment the dermis recovers in. So the question is not which is better.
In short
The difference between the two classes is what actually goes in. hADM (CellRedM · Re2O) places the material the dermis is built from, directly. PN (Rejuran) places no such material — it changes the environment the dermis recovers in. So the question is not which is better but whether you want material added or the environment changed.
Where each one starts
| hADM (CellRedM · Re2O) | PN (Rejuran) | |
|---|---|---|
| Source | Donated human skin with the epidermis and cells removed — dermal matrix | Extracted and purified from salmon and trout |
| Nature | A tissue-derived matrix of collagen, elastin and more | A single long-chain polymer |
| Final form | Lyophilised powder mixed with saline or uncrosslinked HA | Aqueous injectable from the start |
| After placement | It settles in the dermis | It works as it degrades |
| Reversal injection | Not applicable | Not applicable (degradable) |
“Which has the higher molecular weight?” is not a question that holds. PN is a single polymer and is specified in kDa; hADM is a mixture of tissue components, so molecular weight is not a defined quantity for it. The meaningful figure for hADM is how finely it is milled (µm).
PN and PDRN are not different materials either — they are chain-length ranges of the same material, PDRN the shorter, PN the longer.
Adding material, or changing the environment
That one line separates the two classes.
- hADM adds the dermis’s own building material. A matrix of collagen and elastin settles in the dermis and becomes supporting structure.
- PN adds no such material. It forms a water-holding mesh that changes the recovery environment, and degrades as it does so.
- So the session design differs. hADM settles, so the session burden is lighter; PN is built up over a course.
Choosing between them
| If this is the goal | The side that fits |
|---|---|
| A thinned dermis that needs support | hADM — material added directly |
| Fewer sessions | hADM |
| Thin, reactive skin | PN — a degradable material is a lighter start |
| A first booster | PN |
| Texture and feel above all | PN |
| Lost volume | Neither — that is a filling material |
| Both apply | They aim differently, so we separate them in time |
We do not rank them. Products that place different things cannot be put in a single line. Both classes target dermal density and texture, and neither answers for lost volume.
CellRedM and Re2O
| CellRedM | Hans Biomed · Hugel · launched September 2025 |
|---|---|
| Re2O | L&C Bio · Huons Medicare · launched November 2024 |
Both are the same class, and we do not tell patients that one is finer or more refined than the other. In consultation we decide on area and goal. Product pages: CellRedM · Re2O.
Can they be combined
Yes. They place different things, so they do not substitute for each other. But we separate them in time — placed on the same day, a reaction could not be attributed to either.
We place one, review the skin, and then decide the combination and the order. Which goes first is decided by whichever has fallen further.
How we decide
- The goal becomes a sentence first. The class follows from it.
- We do not rank products. Products that place different things cannot be put in a single line.
- Plane first. Both classes target the dermis, and thin areas get less volume.
- For a first booster we offer the degradable material, because it is a lighter commitment.
- Combinations are separated in time. Never on the same day.
Frequently asked questions
How do CellRedM and Re2O differ from Rejuran?
In what actually goes in. hADM places the material the dermis is built from; PN places no such material and instead changes the recovery environment. The choice is not better or worse but which of those you want.
Which has the higher molecular weight?
The question does not hold. PN is a single polymer specified in kDa, but hADM is a mixture of tissue components, so molecular weight is not a defined quantity for it. The meaningful figure there is how finely it is milled.
Are PN and PDRN different materials?
No — they are chain-length ranges of the same material, PDRN the shorter and PN the longer. Products differ in which range they use.
Can either be dissolved?
Neither dissolves with hyaluronidase, because neither is hyaluronic acid. Both are nonetheless degraded by the body, so neither stays in place indefinitely.
How do the sessions differ?
hADM settles, so the session burden is lighter. PN is built up over a course — we run three to four sessions, three to four weeks apart.
Will either restore lost volume?
Neither is a filling product. Both target dermal density and texture. If lost volume is the main concern, that is a filling material.
Is CellRedM or Re2O the better one?
We do not tell patients that one is finer or more refined. They are the same class; in consultation we decide on area and goal.
Who wrote this
Written and reviewed by Lee Chi-Hak, MD, director of Miso Clinic, Daegu. The treatment standards and injection design here are the ones we use in practice.
| Medical director | Lee Chi-Hak, MD |
|---|---|
| Address | 4F Bombom Building, 125 Dongdeok-ro, Jung-gu, Daegu, South Korea · Exit 1, Kyungpook National University Hospital Station |
| Phone | +82-53-428-2700 |
| Hours | Weekdays 11:00–19:00 (lunch 13:00–14:00) / Saturday 10:00–16:00 (no lunch break) / Closed Sundays and public holidays |
| Columns | All clinical columns |
| Reference library | All booster and device references |
This is general medical information and does not replace consultation. Indications, method and whether to treat at all should be decided after examination.
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