Rejuran in Daegu: who is it right for?
Rejuran is better known by its nickname, the “salmon injection”. Who it actually suits is less well known than the nickname. Here is who we suggest it for and who we do not.
The short answer
Rejuran (a PN skin booster) suits skin that is thin and sensitive, where fine lines are starting, and that is dry with rough texture. It does not drive a foreign-body reaction to make collagen; it forms a water-holding mesh that makes the skin’s own recovery easier, so it is gentle on reactive skin.
Among boosters it is unusual in being a material the body breaks down as it works — which is why the starting burden is low, and why we reach for it first with thin, reactive skin and with people having a booster for the first time.
Who Rejuran fits
- Skin that is thin and sensitive, so stronger treatments feel like too much
- Fine lines starting around the eyes and mouth
- Dry, rough texture that makes make-up sit badly
- Shallow acne scarring that leaves the surface uneven
- Wanting to support recovery after laser or RF
- Discomfort with non-reversible materials — PN degrades
When Rejuran is not the answer
- Hollow cheeks or nasolabial area — filler territory.
- Sagging contour — RF lifting works on that layer.
- Deep expression lines — botulinum toxin comes first.
- You want one visible change in one go — Rejuran arrives gradually over a course.
- Fish allergy — proteins are filtered out in purification, but tell us if you have a history.
Healer, HB, HB Plus: what is the difference
| Composition | Character | |
|---|---|---|
| Rejuran Healer | PN alone | The basic formulation. Viscous, so more pain and bumps on injection |
| Rejuran HB | PN + hyaluronic acid | Added hydration; feels dewy right after |
| Rejuran HB Plus | PN + hyaluronic acid + lidocaine | Local anaesthetic makes it the least painful. Miso Clinic’s default |
The manufacturer says it added lidocaine to HB Plus “to reduce pain compared with existing Rejuran”. Read the other way, the original is a painful treatment. We would rather say so. Details in Rejuran HB versus regular Rejuran.
How many sessions
We recommend three to four sessions, three to four weeks apart, as a course. Many people notice change around the second session, and it becomes clear after the course. Why it takes several sessions is in Why Rejuran takes more than one session.
Which treatment fits which concern
| Concern | Treatments to consider | Why |
|---|---|---|
| Fine lines on thin, sensitive skin | Rejuran | No foreign-body reaction |
| Dryness, rough texture, make-up sitting badly | Rejuran HB Plus | PN plus hyaluronic acid hydration |
| Lost density needing material | Re2O, GOURI | Supply or make material |
| Hollow cheeks | Filler class | Boosters do not restore volume |
| Sagging contour | Density / XERF | Radiofrequency for the deeper layer |
| Loss of firmness plus sagging | RF then Rejuran, in sequence | Different layers, so we set an order |
Which treatment is “best” is decided by the state of your skin right now, not by the product. In consultation we look first at what has been lost and what is still there, before we talk about any product name.
Frequently asked questions
From what age?
Condition, not age. Dry, rough skin in your late twenties makes you a candidate; a main problem of sagging in your fifties does not put Rejuran first.
How much does it hurt?
Healer is viscous and does hurt. HB Plus contains lidocaine and is the least uncomfortable; we apply numbing cream for about 30 minutes first.
How long does it last?
We decide by condition rather than by a fixed number. Many people review at about six months after a course, but that is clinic experience rather than a figure we can promise. Rejuran degrades as it works, so it is built up as a continuing course.
GOURI or Rejuran?
They have never been compared directly. The purposes differ: texture and fine lines on thin, sensitive skin points to Rejuran; lost density points to GOURI. See GOURI versus Rejuran.
Read next
If you want to go deeper
Product page
Who wrote this
Written and reviewed by Lee Chi-Hak, MD, medical director of Miso Clinic in Daegu, South Korea. Studies are cited with their size and limitations, and where we could not find data we say so. Individual decisions need an in-person examination; this page does not replace one.
| Medical director | Lee Chi-Hak, MD |
|---|---|
| Address | 4F Bombom Building, 125 Dongdeok-ro, Jung-gu, Daegu, South Korea · Exit 1, Kyungpook National University Hospital Station |
| Phone | +82-53-428-2700 |
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| Reference library | All booster and device references |
Everything on this page is general information and does not replace medical diagnosis or treatment. Effects and side effects vary with individual skin condition, age and underlying illness, and the same result is not guaranteed for everyone. Any decision to proceed should be made in an in-person consultation with a physician.
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