Rejuran HB versus regular Rejuran: what is the difference?
Rejuran is a range, not a single product. The names are confusingly similar, but the difference is exactly one thing: what was added to the PN.
The short answer
Rejuran Healer is PN alone, Rejuran HB is PN plus hyaluronic acid, and Rejuran HB Plus adds a local anaesthetic (lidocaine) on top. The PN dose and role are the same; hydration and pain differ. It is not that one is better: thin, sensitive areas and pain-sensitive people suit HB Plus, and people who prefer the basic formulation suit Healer. Miso Clinic uses HB Plus by default.
In one table
| Composition | Pain | Right after | |
|---|---|---|---|
| Rejuran Healer | PN alone | More — it is viscous | Bumps at injection points for a few days |
| Rejuran HB | PN + HA | Softer than Healer | Dewy feel |
| Rejuran HB Plus | PN + HA + lidocaine | Least | Dewy, less discomfort during treatment |
HB’s hyaluronic acid is not filler hyaluronic acid
The HA in HB is not cross-linked, unlike the filler type that holds volume for months. It absorbs within days to weeks, hydrating and then disappearing. So “HB gives volume too” is not accurate.
Why add lidocaine
The manufacturer says it added lidocaine to HB Plus “to reduce pain compared with existing Rejuran”. Read the other way, the original hurts. That is why Miso Clinic defaults to HB Plus: if pain makes you abandon the course halfway, you never get the chance to see the result.
So when is Healer used
Lidocaine allergy, not wanting added HA, or continuing a course already started on Healer. The PN does the same job in all three, so Healer is not “less effective”.
Which treatment fits which concern
| Concern | Treatments to consider | Why |
|---|---|---|
| Thin, sensitive areas such as eyes and mouth | Rejuran HB Plus | Least discomfort |
| Particularly dry skin | Rejuran HB or HB Plus | Non-cross-linked HA hydration |
| Lidocaine allergy | Rejuran Healer or HB | No lidocaine |
| Prefer the basic formulation | Rejuran Healer | PN alone |
Which treatment is “best” is decided by the state of your skin right now, not by the product. In consultation we look first at what has been lost and what is still there, before we talk about any product name.
Frequently asked questions
Is HB Plus more effective than Healer?
Same PN dose and role. Pain and hydration differ; there is no basis for a bigger effect on lines or texture.
Will HB’s hyaluronic acid puff up my face?
It is non-cross-linked and absorbs within days to weeks. No lasting volume like filler.
Can I switch from Healer to HB Plus mid-course?
Yes. The PN is the same. If pain was the problem, switching helps you finish the course.
Read next
If you want to go deeper
Product page
Who wrote this
Written and reviewed by Lee Chi-Hak, MD, medical director of Miso Clinic in Daegu, South Korea. Studies are cited with their size and limitations, and where we could not find data we say so. Individual decisions need an in-person examination; this page does not replace one.
| Medical director | Lee Chi-Hak, MD |
|---|---|
| Address | 4F Bombom Building, 125 Dongdeok-ro, Jung-gu, Daegu, South Korea · Exit 1, Kyungpook National University Hospital Station |
| Phone | +82-53-428-2700 |
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| Hours | Weekdays 11:00–19:00 (lunch 13:00–14:00) / Saturday 10:00–16:00 / Closed Sundays and public holidays |
| Treatment guides | All guides |
| Comparisons | All comparisons |
| Columns | All clinical columns |
| Reference library | All booster and device references |
References
- Rejuran approval phase 3 trial — J Korean Med Sci 2014;29(Suppl 3):S201–S209 (Seoul National University Bundang Hospital). 72 enrolled, 70 analysed, randomised, double-blind, split-face, control was a hyaluronic acid product. Three sessions two weeks apart, 12-week follow-up.
- PharmaResearch product material — Rejuran Healer (PN alone), Rejuran HB (PN + HA), Rejuran HB Plus (PN + HA + lidocaine).
- Biomolecules 2025 — proposed molecular-weight boundary between PDRN (50–1,500 kDa) and PN (above 1,500 kDa).
Everything on this page is general information and does not replace medical diagnosis or treatment. Effects and side effects vary with individual skin condition, age and underlying illness, and the same result is not guaranteed for everyone. Any decision to proceed should be made in an in-person consultation with a physician.
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