Looking into Re2O (hADM) in Daegu — what we settle first

1. We separate what has been lost — sometimes Re2O is not the answer

Re2O targets dermal density and texture. So if the main concern is volume that has deflated in the cheek or temple, or a jawline that has descended, the direction is different — Re2O is not a volumising product, and sagging belongs to the layer radiofrequency lifting works on. Re2O drops off the list at this step more often than people expect.

2. We settle the layer and the area

Re2O goes into the dermis. Dermal thickness differs by area, so in thin areas we reduce the volume and divide the entry points. Around the eyes, where skin is thin and reactive, a finer-particle product in the same class can be the better fit, so we divide within the class by area. The per-area detail is in CellRedM and Re2O — same hADM, what differs.

3. We tell you what room there is to reverse it

hADM is not hyaluronic acid, so dissolving it with hyaluronidase is not a concept that applies. It is, however, a material the body breaks down, so it is not a structure that stays there permanently. With a material that has no reversal injection, we design it to start short and add later.

4. We check what is already in there

If an irreversible material (PCL, PLLA, CaHA) is already in the same area, then if a reaction appears later there is no way to tell which one caused it. So we go through the treatment history area by area. It is the same reason we do not layer several classes on the same day.

5. We give you the session plan and the contact threshold

We start Re2O on three sessions a month apart, and decide on more by the state of the skin, not by the calendar. We do not set a package first and then fill it. Last, we tell you what to watch for after treatment and when to call — pain in one spot lasting more than two days, a change in colour, or swelling that grows again means call us rather than wait.

Re2O is the matrix left after cells are removed from donated human dermis. That it comes from a person is reflected directly in how it is handled.

• The chain of custody is tight. Donation, processing, testing, storage and distribution are all recorded — tighter, in fact, than for synthetic-polymer classes.
• Safety is managed in several layers: donor screening and serology, viral inactivation during processing, and the decellularisation step that removes the cell antigens and DNA that drive immune response.
• It uses the building material the body already contains — a different starting point from a synthetic material.

We tell you the origin before the decision, not after. Choosing with that in hand is not the same as choosing without it, and if it does not sit right with you we do not press it — there are other classes for the same goal.

• We do not say “this product is the best.” Products that aim at different things cannot be put in one line.
• We do not present testimonials or before-and-after photographs as evidence of effect (Medical Service Act, Article 56(2)).
• We do not use words like “no side effects,” “the best,” “the only.”
• We do not explain the material while leaving out where it comes from. We say it first, and you decide.
• We do not ask for a same-day decision. With a material that has no reversal injection, hurrying the decision moves the risk onto the patient.
• We do not talk down another clinic’s work.
• We do not discuss prices in columns or on the website. When price comes first in the order of judgement, there is less room to settle goal, layer, volume and sessions.

1. “In my case, is this a texture problem, a volume problem or a sagging problem?” — a product chosen without that distinction can point the wrong way.
2. “What does this material actually place?” — hADM places the dermis’s own building material. That is different from a material that signals.
3. “Which layer, and into how many points?” — in thin areas this is what decides the result.
4. “Can it be reversed?” — hADM is not a material hyaluronidase dissolves. It is, though, one the body breaks down.
5. “What should I watch for afterwards, and when do I call?” — check that there is a threshold and a number.

• Types of skin booster compared — what each class targets

Written and reviewed by Lee Chi-Hak, MD, director of Miso Clinic, Daegu. The treatment standards and injection design here are the ones we use in practice.