How does REALLO treatment go, and how long is recovery?
“How long does it take?” “Can I go straight back to work?” These questions always come up before treatment. Apart from mixing the powder just before treatment, REALLO follows much the same flow as other hADM treatments. Here it is in the order we actually do it in the treatment room.
The short answer
REALLO treatment goes consultation → numbing cream → mixing just before treatment → injection into the dermis in divided amounts with a fine needle, and takes about 30–40 minutes including numbing. Right after treatment the injection points may be slightly raised and red; this usually settles within a few days. If bruising appears, it can take 1–2 weeks. Changes show gradually over several weeks, and the next session is decided after seeing how the first goes. At Miso Clinic, 4F Bombom Building, 125 Dongdeok-ro, Jung-gu, Daegu (Exit 1, Kyungpook Nat'l Univ. Hospital Station), +82-53-428-2700, we check the genuine product box and human-tissue labelling with you before treatment.
What happens in the consultation before treatment?
- Sorting out the concern — first we separate thinned skin, density and texture from hollowing and sagging. REALLO does not create volume
- Human-tissue disclosure — I tell you the material comes from donated human skin. If that makes you uncomfortable, we plan with a different class
- Health check — I ask about pregnancy or breastfeeding, infection at the treatment site and any history of allergy
- Genuine product check — we look at the product box, the sterility mark and the expiry date together
In what order is the treatment done?
- 1Cleansing, numbing creamThe numbing cream goes on and we wait. This wait is a large share of the total time.
- 2Mixing just before treatmentThe powder syringe and the fluid syringe are joined with a connector and pushed back and forth end to end at least 30 times (official instructions). The amount of fluid is set for the area.
- 3InjectionWith a fine needle, the material is placed into the dermis at many separate points. I do not put it all in one spot.
- 4Finishing, calmingI check the injection sites, calm the skin and go over aftercare before you leave.
It takes about 30–40 minutes including numbing. Each product is used for one person; any remainder is not kept or reused.
Why is it mixed just before treatment?
REALLO is stored as a freeze-dried powder. That is why it can be kept at room temperature (1–30°C) with a shelf life of 5 years from manufacture. Just before use it is hydrated so that it can be injected.
The upside is that the amount of fluid sets the concentration; the point to watch is that if it is not mixed enough, the particles may not be even. So I follow the official instruction of “at least 30 times back and forth” as written.
What is it like after treatment?
| Reaction | Usually | What to do |
|---|---|---|
| Small raised bumps at injection points | Settle within a few days | Do not press or rub them |
| Redness, swelling | Same day to a few days | A light cold compress |
| Bruising | 1–2 weeks if it appears | Cover-up make-up from the next day |
| Increasing warmth or pain, pus | Uncommon | These can be signs of infection — contact us straight away |
How long each lasts depends on your skin and the amount injected. The table describes the course commonly seen with hADM treatment; I have not yet found a study of recovery under the REALLO product name.
When can I get back to normal?
- Gentle face washing from the evening of the treatment day, make-up from the next day
- Avoid saunas, hard exercise and alcohol for the first two days, and take care for about a week
- Put off facial massage and gua sha for the first week
- Blood donation may be restricted under the rules on human tissue grafts — mention the treatment at the pre-donation screening
When do changes show, and how many sessions?
This is not a filling treatment, so nothing changes overnight. Changes show gradually over several weeks. There is no standard number of sessions set by research, so we look at photos of the first session taken under the same conditions and decide the next step together. I do not recommend bundling several sessions from the start.
REALLO treatment: frequently asked questions
How long does REALLO treatment take?
About 30–40 minutes including numbing cream. Waiting for the numbing takes a while, and there is a step where the powder is mixed with hydration fluid just before treatment.
Can I go straight back to work after REALLO?
Usually, yes. The injection points may be slightly raised or red for a few days, and if bruising appears it can take 1–2 weeks. Let me know in advance if you have an important event.
How many REALLO sessions do I need?
There is no standard number set by research. We decide on the next session together after seeing how the first one goes.
Where can I get REALLO treatment in Daegu?
At Miso Clinic, 4F Bombom Building, 125 Dongdeok-ro, Jung-gu, Daegu (Exit 1, Kyungpook Nat'l Univ. Hospital Station), +82-53-428-2700. Weekdays 11:00–19:00, Saturday 10:00–16:00, closed Sundays and public holidays.
Read next
Product pages
Read alongside: REALLO INJECT FINE (hADM): its strengths · Rituo (Re2O) · CellREDM
Who wrote this
Written and reviewed by Lee Chi-Hak, MD, director of Miso Clinic, Daegu. The treatment standards and injection design set out here are the ones we use in practice.
| Medical director | Lee Chi-Hak, MD |
|---|---|
| Address | 4F Bombom Building, 125 Dongdeok-ro, Jung-gu, Daegu, South Korea · Exit 1, Kyungpook National University Hospital Station |
| Phone | +82-53-428-2700 |
| Hours | Weekdays 11:00–19:00 (lunch 13:00–14:00) / Saturday 10:00–16:00 (no lunch break) / Closed Sundays and public holidays |
| Columns | All clinical columns |
| Reference library | All booster and device references |
References
- REALLO INJECT FINE product information — CGBio official product page (cgbio.co.kr, REALLO INJECT FINE): particulate freeze-dried acellular allogeneic dermis (mADM), human tissue; a powder-filled syringe with a 2-way connector; mixed back and forth with 3–5 cc of hydration fluid at least 30 times; stored at room temperature (1–30°C); shelf life 5 years from manufacture; antibiotic treatment followed by terminal irradiation sterilisation; for one patient, with no reuse; patients told in advance that it is human tissue; blood donation may be restricted; stated performance and purpose “restoring skin and soft-tissue defects”. The product photo is also from this page.
- Miso Clinic practice guidelines (hADM) — the genuine product box and human-tissue labelling checked before treatment; about 30–40 minutes including numbing cream; volume concerns handled separately; sessions not bundled from the start; not done during pregnancy or breastfeeding or with infection at the treatment site; a non-human-derived plan offered to anyone uncomfortable with human tissue.
- Miso Clinic hADM pages — /en/re2o/ · /en/cellredm/ · the column “CellREDM vs Rituo”: Rituo is made by L&C Bio, with a randomised, double-blind split-face trial in 20 people over 20 weeks (hyaluronic acid control; Lee YI et al., Int J Mol Sci 2026;27:2193). CellREDM is made by Hans Biomed with distribution rights held by Hugel, particle size about 75μm (manufacturer’s figure).
- Korean medical advertising law — Korean Medical Service Act Article 56(2) (no treatment testimonials, no comparisons with other clinics, no superlatives). This is why this column carries no prices, reviews or before-and-after photos.
Everything in this column is general information and does not replace medical diagnosis or treatment. Effects and side effects vary with individual skin condition, age and underlying illness, and the same result is not guaranteed for everyone. Any decision to proceed should be made in an in-person consultation with a physician.