Miso Clinic · Clinical column

What is different about lifting for men

Male patients are increasing, and the phrase “male protocol” is often seen. We looked for the evidence. The result was not what we expected — among more than 60 studies of radiofrequency and ultrasound lifting, not one reported results broken down by sex. One meta-analysis had 142 men inside its data and yet produced not a single line of results for men. We have written it exactly as we found it.

Clinical column About a 12-minute read September 2026 Miso Clinic, Daegu · Dr. Lee Chi-Hak

The conclusion, first

In lifting for men, the only sex difference with solid evidence is botulinum toxin dose — in a dose-ranging randomised trial of 80 men, a starting dose of at least 40 units for the glabella was recommended (the standard for women is 20 units). Men's facial skin genuinely is thicker — in ultrasound measurements of 200 Chinese subjects, men were thicker in all 16 site · age-group combinations, and in a study including Korean subjects, men's facial skin thinned less with age. That said, the original source of the widely quoted “men’s skin is 20 to 25% thicker” was not the face but the forearm. And male-specific guidelines for lifting devices do not exist, a fact the field itself acknowledges. Current recommendations for lifting in men are mostly carried over from data on women.

First — how far the evidence actually goes

Articles about treatments for men usually begin with “men are different in these ways”. This article begins the other way round. Let us start with what has been tested.

Reporting of sex in the main lifting literature
PublicationSizeSex-stratified results
Ultrasound lifting systematic review (2023)16 studies“All studies were conducted in female patients”
Ultrasound meta-analysis (2025)475 patients — 333 women · 142 menNone. Sex is mentioned only in a single demographic line
Ultrasound systematic review (2025)45 studiesNot even the sex distribution is reported
Radiofrequency multicentre study (2026)39 patients — 37 women · 2 menThe paper itself states that “with only 2 men, generalisation to male patients is limited”

These four publications independently cover more than 60 clinical studies. Among them we could not identify a single study reporting efficacy results broken down by sex.

The second row is particularly striking. Data on 142 men were already inside the analysis, and yet not a single line of results for men came out of it. It is not that the data were absent; it is that nobody broke them down.

The limitations section of the systematic review of 16 studies is also notable — the authors themselves wrote that “since male skin is different, it would be interesting to know whether these results are reproduced in men”.

So the premise of this article is this. The recommendations for lifting in men now in circulation are mostly carried over from data on women. That does not mean they are wrong, but we will not mix what has been verified with what has been carried over.

Men’s facial skin genuinely is thicker — but the familiar number is not a facial one

The sentence “men's skin is 20 to 25% thicker” appears often. We looked for the original source.

The abstract of the 1975 paper this figure traces back to opens as follows — “Collagen, dermal thickness and collagen density of forearm skin were measured.” The forearm, not the face. And the abstract contains no percentage figure.

So we replaced it with Asian data actually measured on the face.

Skin thickness by facial site — ultrasound measurement of 200 Chinese subjects (women / men, mm)
SiteAged 20 to 29Aged 50 to 70
Forehead1.86 / 2.451.64 / 2.28
Cheek1.90 / 2.531.89 / 2.38
Lateral canthus1.36 / 1.641.36 / 1.73
Eyelid1.24 / 1.441.16 / 1.58

Wang X et al., Chinese Journal of Burns 2020. 200 Chinese adults (100 men · 100 women), 50MHz high-frequency ultrasound. An important caveat — the statistical testing in this paper compared age groups within the same sex, and did not directly test the difference between men and women. That men were thicker in all 16 combinations is something we established by placing the published mean values side by side.

There is also a study that did directly test the difference between the sexes. In a study of 118 people measuring 8 facial sites, the epidermis and dermis were significantly thicker in men than in women (with the malar epidermis and the neck dermis as the only exceptions).

And a clinically more interesting finding came out of that study.

In women, the skin thinned with age at the forehead · glabella · malar area · submandibular region, whereas in men an age correlation appeared at only one site, the malar dermis. In other words, men's facial skin thins less with age. This is a favourable condition for men — the tissue being treated is thicker and shrinks less over time.

Bone ages in the same direction in both sexes

The explanation that “men and women age skeletally at different times” is often seen. We checked the papers cited as evidence for it.

In a 2011 study measuring 120 white subjects with three-dimensional CT and a 2007 study of 60 subjects, every finding was described as occurring “in both sexes” — widening of the orbital aperture, a decrease in the glabellar angle and an increase in the mandibular angle were all significant in both sexes. A difference between the sexes in the timing of these changes is not reported in the abstracts of these papers.

Korean data point the same way.

  • CT study of 114 Korean subjects: the canine fossa angle (the concavity at the front of the cheek) decreased significantly in both sexes.
  • CT study of the forehead in 180 Korean subjects: the forehead flattened in both sexes. Men simply start from a more sloped forehead when young.

So we could not find evidence for the claim that “men age at a different time, so they should start at a different time”. What has been confirmed is that men and women change in the same direction. What differs is the starting point — men's forehead slope, mandibular angle and brow position begin in a different place to start with.

One sex difference with solid evidence — toxin dose

This is the only item in this article for which we can state flatly that “men are different in this way”. There is a dose-ranging randomised trial conducted in men only.

Dose-ranging trial of glabellar botulinum toxin in men
ItemDetail
DesignProspective · double-blind · randomised · parallel-group — men only
Subjects80 men
AllocationTotal of 20 · 40 · 60 · 80 units to the glabella
Results40 units consistently superior to 20 units. Both response rate and duration increased with dose. Adverse events also increased at higher doses
Conclusion“Men benefit from a starting dose of at least 40 units”

Carruthers A · Carruthers J, Dermatologic Surgery 2005;31(10):1297-1303.

Compared with the standard glabellar dose of 20 units in women, that is double. The reason is muscle mass.

However, the same trial reports that adverse events also increased with dose. And in other data, satisfaction by dose was 60% at 40 units → 51% at 60 units → 39% at 80 units. It is not that more is better, but that the starting point is different.

“More masculine” is hard to justify as a goal

When treatments for men are described, the phrase “enhancing the masculine contour” is common. What relationship this actually has with attractiveness has been measured.

These are the results of a 2023 study analysing 1,550 faces across 10 cultures.

Contribution to attractiveness — 1,550 faces across 10 cultures
FactorCoefficientInterpretation
Femininity in female faces0.24 [89% confidence interval 0.16, 0.32]Raised attractiveness in every culture
Masculinity in male faces−0.03 [−0.10, 0.05]Confidence interval includes 0 — no effect
Degree of deviation from the averageLowered attractiveness in both sexes
SymmetryNo effect

Kleisner K et al., Evolution and Human Behavior 2023. 10 countries (Brazil · Cameroon · Czechia · Colombia · India · Namibia · Romania · Türkiye · the United Kingdom · Vietnam), 72 landmarks. No Korean sample is included.

In other words, the premise that “making a face more masculine makes it more attractive” has no evidence behind it. Unlike the contribution femininity made in female faces, masculinity in male faces had an effect close to zero.

What consistently lowered attractiveness in both sexes was “the degree of deviation from the average”. We have written about this topic in detail in what is the difference between a natural face and an artificial one?.

So setting the goal of treatment in men as “reducing what catches the eye” rather than “more masculine” fits the evidence. Conversely, we should also state that the concern that excessive volume makes a face look feminine has no measured data behind it either and rests only on expert opinion.

Something that has never been tested at all — beards

This subject always comes up when treatments for men are discussed, but this section is short. That is because we found almost nothing.

  • “The skin of the beard area is more richly vascularised” — we could not find a study measuring this in humans. The search results were literature on shaving and studies of hair follicle vasculature in mice.
  • “So it bruises more easily” — no studies.
  • “A beard affects radiofrequency electrode contact or ultrasound transmission”we could not find evidence of any kind. It is a completely untested area.
  • A comparison of beard density between Korean men and Western men — we could not find data.

You must not read this as “there is no effect”. It is “it has never been tested”. When we treat the beard area cautiously in practice, we say so while stating that this is experience, not evidence.

What male patients actually want — and pain

There is one dataset on Asian men. It surveyed 302 men at the cosmetic consultation clinic of a university hospital dermatology department in Thailand.

  • Motivation: improving appearance 88.4%, career · work 10.3%, peer pressure 9.6%
  • Downtime: 81.5% preferred “gradual improvement with no downtime”. Those willing to accept a recovery period and resolve everything at once were 18.5%
  • Willingness to accept treatments: lasers 75.8%, injectables 61.9%

Girdwichai N et al., JCAD 2018. This is not a lifting patient population but one in which acne · hair loss consultations predominate, and it is not Korean data. Even so, it is the largest dataset on Asian men that we found.

On pain, what has been measured points to there being no sex difference. In a study comparing 84 people who had facial laser treatment (42 men · 42 women), there was no statistically significant sex difference in mean pain. The authors concluded that pain tolerance for non-invasive procedures could be expected to be similar regardless of sex.

However, this study was on lasers, not radiofrequency or ultrasound. We could not find comparative data on sex differences in pain with lifting devices. Neither “you are a man, so bear it” nor “men feel more pain” has evidence behind it.

What the field itself acknowledges

In 2025 a Korean research group published an ultrasound lifting protocol for Asian men. That paper contains this sentence.

“Although guidelines optimising ultrasound lifting have been developed, specific guidance for applying it to men does not currently exist.”

The paper itself is also not randomised, has no control group, does not state the number of patients, and has no quantitative outcome measures. In the authors' own words, it is “our experience”.

In other words, male lifting protocols exist, but they are experience, not evidence. And the field has written that fact down itself.

The reason we go out of our way to quote this sentence is that honesty is how this site works. There is at present no basis for packaging treatments for men as something special under the name of a “male-only protocol”.

How we treat male patients at Miso Clinic

  1. We start toxin at a different dose. At least 40 units for the male glabella — the only item supported by a randomised trial conducted in men only. That said, we do not simply raise the dose without limit. Dose and satisfaction were not proportional.
  2. We build the thicker skin into the plan. In facial ultrasound measurements men were thicker across the sites generally, and thinned less with age. That means the tissue being treated is thicker.
  3. We do not set the goal as “more masculine”. Masculinity in male faces did not contribute to attractiveness (coefficient −0.03). Reducing what catches the eye fits the evidence.
  4. We ask about downtime first. In a survey of 302 Asian men, 81.5% preferred gradual improvement with no downtime. We do not take a design that changes a great deal at once as the default.
  5. We do not call it a “male-only protocol”. There is no trial supporting such a thing. Instead we plan by the same criteria — thickness · fat volume · degree of laxity — which we have set out in lifting treatments should differ according to skin thickness and fat volume.
  6. We treat the beard area cautiously, while stating that this is experience. There is no measured evidence.

In summary

  • Strong evidence — glabellar toxin in men should start at a minimum of 40 units. A double-blind randomised dose-ranging trial in 80 men.
  • Moderate evidence — men's facial skin is thicker (ultrasound measurement of 118 · 200 Asian subjects) and thins less with age.
  • Disproved — “making a face more masculine makes it more attractive”. Across 1,550 faces in 10 cultures, the coefficient for masculinity was −0.03, meaning no effect.
  • Disproved — a sex difference in pain. In a comparison of 84 people there was no significant difference (though this was laser data).
  • No evidence — that radiofrequency · ultrasound work differently in men. Of more than 60 studies, 0 reported sex-stratified results.
  • Never tested — the effect of the beard area on vasculature · bruising · device transmission. We could not find evidence of any kind.
  • Correction — the original source of “men's skin is 20 to 25% thicker” is the forearm, not the face.

So the conclusion of this article is not “men are different in these ways” but “almost nothing has been verified in men yet”. That does not mean we should not treat men. It means we apply the one thing that has been verified (toxin dose) firmly, and plan the rest by that person's thickness · fat volume · degree of laxity rather than by sex. Not filling the space where evidence is absent with the label “male-only” is, we think, the honest approach.

Frequently asked questions

Is lifting for men really different from lifting for women?

To be honest, almost nothing has been verified in men. Four publications on radiofrequency and ultrasound lifting independently cover more than 60 clinical studies, and among them we could not identify a single study reporting efficacy results broken down by sex. One meta-analysis had 142 men inside its data and yet produced not a single line of results for men. The 2025 paper on an ultrasound protocol for Asian men also states of itself that “specific guidance for applying it to men does not currently exist”.

Do men need more Botox?

This is the one sex difference with solid evidence. In a double-blind randomised dose-ranging trial conducted in 80 men only, with 20, 40, 60 and 80 units allocated to the glabella, 40 units was consistently superior to 20 units and both response rate and duration increased with dose. The conclusion was that “men benefit from a starting dose of at least 40 units”. Since the standard for women is 20 units, that is double. However, adverse events also increased at higher doses in the same trial, and in other data satisfaction by dose was 60% at 40 units, 51% at 60 units and 39% at 80 units.

Is it true that men's skin is 20 to 25% thicker?

The original source of that figure is the forearm, not the face. The abstract of the 1975 paper opens with “collagen, dermal thickness and collagen density of forearm skin were measured”, and there is no percentage figure in the abstract either. There is separate Asian data actually measured on the face — in ultrasound measurements of 200 Chinese subjects men were thicker in all 16 site and age-group combinations, and in a study of 118 people measuring 8 facial sites the epidermis and dermis were significantly thicker in men.

Does men's skin thin less with age?

That is how the measured data came out. In a study of 118 people measuring 8 facial sites with high-frequency ultrasound, in women the skin thinned with age at the forehead, glabella, malar area and submandibular region, whereas in men an age correlation appeared at only one site, the malar dermis. It means the tissue being treated is thicker and shrinks less over time, which is a favourable condition for men.

Is a treatment that enhances the masculine contour a good thing?

That premise has no evidence behind it. In a 2023 study analysing 1,550 faces across 10 cultures, femininity in female faces raised attractiveness significantly (coefficient 0.24), but masculinity in male faces had a coefficient of −0.03 with a confidence interval that includes 0, meaning no effect. What consistently lowered attractiveness in both sexes was “the degree of deviation from the average”. Setting the goal as “reducing what catches the eye” rather than “more masculine” fits the evidence. That said, the concern that excessive volume makes a face look feminine also rests only on expert opinion, with no measured data.

Does having a beard affect treatment?

We could not find evidence of any kind. “The skin of the beard area is more richly vascularised”, “so it bruises more easily”, “a beard affects radiofrequency electrode contact or ultrasound transmission” — for all three we could not find a study measuring it in humans. There is no data comparing beard density between Korean and Western men either. You should not read this as “there is no effect” but as “it has never been tested”. Our treating the beard area cautiously is experience, not evidence.

Do treatments hurt more or less for men?

What has been measured points to there being no difference. In a study comparing 84 people who had facial laser treatment (42 men, 42 women), there was no statistically significant sex difference in mean pain, and the authors concluded that pain tolerance for non-invasive procedures could be expected to be similar regardless of sex. However, this study was on lasers, not radiofrequency or ultrasound, and we could not find comparative data on sex differences in pain with lifting devices.

What do male patients mainly want?

In a survey of 302 Asian men, the motivations for considering treatment were improving appearance 88.4%, career or work 10.3%, and peer pressure 9.6%. The most striking finding is their attitude to downtime — 81.5% preferred “gradual improvement with no downtime”, while those willing to accept a recovery period and resolve everything at once were 18.5%. That said, this survey was not of a lifting patient population but of one in which acne and hair loss consultations predominate, and it is not Korean data.

Who wrote this

Written and reviewed by Lee Chi-Hak, MD, medical director of Miso Clinic in Daegu, South Korea. Every study cited above is given together with its design, its size and the limitations the authors themselves recorded, and where we could not find data, we have said that we could not find any.

Miso Clinic
Medical directorLee Chi-Hak, MD
Address4F Bombom Building, 125 Dongdeok-ro, Jung-gu, Daegu, South Korea · Exit 1, Kyungpook National University Hospital Station
Phone+82-53-428-2700
HoursWeekdays 11:00–19:00 (lunch 13:00–14:00) / Saturday 10:00–16:00 (no lunch break) / Closed Sundays and public holidays
ColumnsAll clinical columns
Reference libraryAll booster and device references

References

  1. The absence of sex-stratified results was confirmed in Contini M et al. (corresponding author Schortinghuis J), IJERPH 2023;20(2):1522 (16 studies — “all studies were conducted in female patients”, and “since male skin is different, it would be interesting to know whether these results are reproduced in men”), Modena DAO et al., Lasers Med Sci 2025;40:169 (475 patients — 333 women · 142 men, sex mentioned only in a single demographic line), Haykal D et al., Aesthet Surg J 2025;45(7):690-698 (45 studies, not even the sex distribution reported) and Cureus 2026 (39 patients — 37 women · 2 men, the paper itself recording the limit on generalisation).
  2. The original source of “men's skin 20 to 25%” is Shuster S et al., Br J Dermatol 1975;93(6):639-643, and the site measured was the forearm. There is no percentage figure in the abstract, and the sample is described only as “a large number of normal subjects”, so we could not verify the exact n.
  3. Facial skin thickness is from Wang X et al., Chinese Journal of Burns 2020 (200 Chinese adults, 50MHz ultrasound — the statistical testing in this paper compared age groups within the same sex and did not directly test the difference between men and women. That men were thicker in all 16 combinations is the published mean values placed side by side) and Meng Y et al., BMC Med Imaging 2022;22:113 (118 people, 8 sites — epidermis · dermis significantly thicker in men, excepting the malar epidermis and the neck dermis; in men an age correlation at only one site, the malar dermis). Jeong KM et al., Skin Res Technol 2023 points the same way, but we could not verify its sample size or the figures by site.
  4. The facial skeleton data are Shaw RB Jr · Kahn DM, Plast Reconstr Surg 2007;119(2):675-681 (60 white subjects) and Shaw RB et al., Plast Reconstr Surg 2011;127(1):374-383 (three-dimensional CT). The abstracts of both papers describe the changes as occurring “in both sexes” and do not report a difference between the sexes in the timing of change. We could not verify the widely cited statement that “men and women age at different times” in the original texts. The Korean data are Jeon A et al., Folia Morphol 2017;76(4):730-735 (114 subjects — the canine fossa angle decreased significantly in both sexes) and Yi HS, Arch Craniofac Surg 2015;16(2):58-62 (180 subjects — the forehead flattened in both sexes).
  5. The toxin dose for men is from Carruthers A · Carruthers J, Dermatologic Surgery 2005;31(10):1297-1303 (prospective · double-blind · randomised · parallel-group, 80 men only, glabella at 20/40/60/80 units — “men benefit from a starting dose of at least 40 units”). The satisfaction-by-dose figures are a citation via a review article, and we could not verify the original trial directly.
  6. The attractiveness data are from Kleisner K et al., Evolution and Human Behavior 2023 (10 countries, 1,550 faces, 72 landmarks, Bayesian multilevel regression — femininity 0.24 [89% CI 0.16, 0.32], masculinity −0.03 [−0.10, 0.05]). Of the 10 countries the only East Asian sample is Vietnam, and there is no Korean sample.
  7. The survey of male patients is Girdwichai N et al., J Clin Aesthet Dermatol 2018;11(3):42-48 (Thailand, 302 men · 305 women as a comparison group, university hospital dermatology cosmetic clinic). This is not a lifting patient population but one in which acne · hair loss consultations predominate, and it is not Korean data. Pain is from Orringer JS et al., J Cosmet Laser Ther 2014;16(5):253-257 (84 people — 42 men · 42 women, no significant sex difference), and it is a laser treatment, not radiofrequency · ultrasound.
  8. The level of evidence for male protocols is from Park JY et al., J Cosmet Dermatol 2025;24(6):e70278 (Korea, ultrasound lifting in Asian men). It is not randomised, has no control group, does not state the number of patients, and has no quantitative outcome measures. The sentence quoted in the body text — “although guidelines optimising ultrasound lifting have been developed, specific guidance for applying it to men does not currently exist” — is from this paper.
  9. What we recorded as “we could not find evidence” — the effect of the beard area on vascular distribution · bruising · device transmission, sex differences in the rate of dermal collagen loss, sex differences in the distribution of facial subcutaneous fat (CT · MRI), sex comparisons of pain with radiofrequency · ultrasound, the feminisation risk of excessive volume, comparisons of beard density in Korean men, and statistics on aesthetic treatments in Korean men.
  10. This article does not guarantee the efficacy of any particular treatment. Indications and expected results vary with each individual's condition, and consultation through an examination is necessary.

Everything in this column is general information and does not replace medical diagnosis or treatment. Effects and side effects vary with individual skin condition, age and underlying illness, and the same result is not guaranteed for everyone. Any decision to proceed should be made in an in-person consultation with a physician.

← Clinical columns · Reference library · Miso Clinic home

한국어 · English · 日本語 · 简体中文 · Español · Tiếng Việt · ภาษาไทย · Bahasa Indonesia