There are so many skin boosters. Which one suits my skin?
“Rejuran, Lituo, Gouri, Juvelook… I can't tell them apart.” Almost every skin booster consultation starts with this. You don't need to memorise product names first. Once you decide on the one thing that bothers you most right now, the choice narrows down a lot.
The short answer
Skin boosters are easier to choose when you start from the concern, not the product name. For texture and glow, Rejuran (PN); for thinned skin, a material-replenishing type such as Lituo (hADM); for firmness across the whole face, Gouri (liquid PCL); for shallow hollows, a collagen booster such as Juvelook Skin; for pores, oil and fine lines, skin botox. If you have two concerns, we combine two. The combinations I often suggest at Miso Clinic are Rejuran + skin botox and Lituo + radiofrequency lifting. There is no ranking of which product is better; each one simply suits different skin. At Miso Clinic in Daegu, I start by looking at your skin thickness and the one thing that bothers you most.
What groups do skin boosters fall into?
| Concern | Group | What we use at Miso Clinic | What to expect, and the limits |
|---|---|---|---|
| Rough texture, not enough firmness | Regenerative (PN) | Rejuran | Texture and firmness. Volume does not change, and the evidence is low to moderate |
| Skin has thinned and lost density | Material-replenishing (hADM) | Lituo (Re2O) · CellReDM · Reallo | Replenishes the base. Not an injection that fills hollows |
| Texture and firmness across the whole face | Liquid PCL | Gouri | Spreads widely. Human data total 33 people, up to 6 months |
| Texture plus shallow hollows | Collagen booster (PDLLA) | Juvelook Skin | Builds up over weeks to months |
| Pores, oil, fine lines | Skin botox | Skin botox | Wears off after 3–4 months |
As the table shows, things that are all called “skin boosters” do quite different jobs. So a product that suited a friend won't necessarily suit your face.
→ Read more: Choosing a skin booster
If I have two concerns, how are they combined?
- Rejuran + skin botox → texture together with pores and oil. If we split the areas, both can be done the same day
- Lituo + radiofrequency lifting → when thinned skin also sags
- Gouri + radiofrequency lifting → when firmness has dropped across the face and the contour has blurred too
- Hyaluronic acid filler + Rejuran → filler for deep hollows, Rejuran for surface texture
To be honest, I couldn't find trials showing that combining works better than doing just one. We do two because there are two concerns. I set the order and interval after looking at the skin.
→ Read more: Skin booster or lifting?
Does the choice change with age?
I don't draw lines by age. That said, people in their 20s and 30s often worry about texture and pores, so the talk tends to be about Rejuran or skin botox, and quite often sunscreen, moisturising and barrier care come first.
In the 40s and 50s, thinning, dryness, loss of firmness and hollowing tend to arrive all at once. Then I go through what has decreased, one by one, and split it by group.
→ Read more: A skin booster consultation
Does the eye area need to be looked at separately?
Yes. The dermis around the eyes is thin, so depending on particle size and injection depth, product can clump or show through with a bluish tint. So I don't use the same product in the same way as on the rest of the face.
→ Read more: Skin boosters around the eyes
When a skin booster isn't the answer
- If the cheeks or temples have hollowed deeply, I look first at dissolvable hyaluronic acid filler.
- If a dropped jawline is the main concern, a booster alone falls short. Lifting comes first.
- If you have a fixed date such as a wedding, we count backwards from when results show and plan from there.
→ Read more: When do results show?
How does the consultation work, and how do I book?
On a first visit we take photos from the front, at 45 degrees and from the side, and together we pick the one concern that bothers you most. I'll ask about any medications you take, any metal or electronic implants in your face, and whether you might be pregnant, and then I split things into what we can do today and what can wait for later. It's completely fine to come in just for a consultation and go home.
| Item | Details |
|---|---|
| Booking | Naver booking · KakaoTalk chat · Phone +82-53-428-2700 |
| Location | 4F Bombom Building, 125 Dongdeok-ro, Jung-gu, Daegu (Exit 1, Kyungpook National University Hospital Station, Line 3) |
| Hours | Weekdays 11:00–19:00 · Saturday 10:00–16:00, closed Sundays and public holidays |
Types of skin booster FAQ
It's my first skin booster. What should I start with?
Decide on the one thing that bothers you most and start with that group. Rejuran for texture, Lituo for thinning, and so on.
Can I have several at once?
If you have two concerns, we combine them. But there's no evidence that doing them together works better, so I don't add anything you don't need.
When will I see results?
With products that prompt collagen, no new collagen is visible at 2 weeks; type III increases at about 2 months and type I at 3–4 months. That's why I assess at 2–3 months.
How many sessions will I need?
It differs by product, so I decide after seeing how the first one goes. With Gouri, I check progress at 4 weeks and, if needed, add more at 4–6 week intervals.
Is there one skin booster that works better than the rest?
There's no ranking. Different products simply suit different skin and concerns.
Where can I get a skin booster consultation in Daegu?
At Miso Clinic in Daegu (4F Bombom Building, 125 Dongdeok-ro, Jung-gu, Exit 1 of Kyungpook National University Hospital Station). You can book through Naver booking, KakaoTalk or by phone at +82-53-428-2700. Weekdays 11:00–19:00, Saturday 10:00–16:00, closed Sundays and public holidays.
Read next
Product pages
Related care: Rejuran · Lituo (Re2O) · Gouri · Juvelook
Who wrote this
Written and reviewed by Lee Chi-Hak, MD, director of Miso Clinic, Daegu. The treatment standards and injection design set out here are the ones we use in practice.
| Medical director | Lee Chi-Hak, MD |
|---|---|
| Address | 4F Bombom Building, 125 Dongdeok-ro, Jung-gu, Daegu, South Korea · Exit 1, Kyungpook National University Hospital Station |
| Phone | +82-53-428-2700 |
| Hours | Weekdays 11:00–19:00 (lunch 13:00–14:00) / Saturday 10:00–16:00 (no lunch break) / Closed Sundays and public holidays |
| Columns | All clinical columns |
| Reference library | All booster and device references |
References
- Evidence on PN and PDRN — Miso Clinic column pn-pdrn-difference: the same substance (purified DNA fragments from salmonid fish) with different chain lengths (PDRN short, PN long); I could not find a human trial comparing the two directly; a systematic review of 9 studies and 219 people rated the evidence low to moderate; the main trial had 27 people.
- Human trial of Lituo — Lee YI et al. Int J Mol Sci 2026;27(5):2193. NCT07155278. Split-face, double-blind, randomised, 20 people, 20 weeks.
- Human data on Gouri — Ponzo M et al. PMID 41210393 (30-person pilot study) plus 3 case reports, 33 people in total, up to 6 months.
- Juvelook-type comparison — PDLLA plus hyaluronic acid versus PLLA, split-face in 33 people with smile lines, similar up to 24 weeks. PMID 41532837.
- Cochrane review of botulinum toxin — Camargo CP et al. Cochrane Database Syst Rev 2021;7:CD011301. PMID 34224576. 65 studies, 14,919 people.
- When results show — Miso Clinic column when-results-show: at day 90, 92% of doctors versus 42% of patients. In biopsies after collagen-stimulating products, no new collagen at 2 weeks, type III at 2 months, type I at 3–4 months.
- Korean medical advertising law — Korean Medical Service Act Article 56(2) (no treatment testimonials, no comparisons with other clinics, no superlatives). This is why this column carries no prices, reviews or before-and-after photos.
- Miso Clinic treatment policy — What we have: Density Noir (ALPHA · BOOST tips), XERF, Oligio Kiss; Lituo (Re2O), CellReDM, Reallo; Rejuran; the full Juvelook lineup; Gouri; Everwrinkle and Everwrinkle V; Radiesse; Byryzn; D-Classy; hyaluronic acid filler; botox (all areas, skin botox); ligament injection; dissolving threads. What we do not offer: Onda, Thermage, InMode, Ulthera, Shurink, liposuction. Hollow cheeks get dissolvable hyaluronic acid filler first, sagging gets lifting first; no radiofrequency that day with metal or electronic implants in the face, pregnancy or skin inflammation; threads are the dissolving kind, used conservatively over age 50; we decide by the change that bothers you, not by age; results are judged after 2–3 months with photos taken under the same conditions.
Everything in this column is general information and does not replace medical diagnosis or treatment. Effects and side effects vary with individual skin condition, age and underlying illness, and the same result is not guaranteed for everyone. Any decision to proceed should be made in an in-person consultation with a physician.