Rejuran in Daegu — what goes in and what it targets
Rejuran places polynucleotide (PN), purified from salmonid fish, into the dermis. It is not a filler — it changes the environment the dermis recovers in — and it is a material the body breaks down. What goes in, which plane it targets, and what becomes visible when.
In short
Rejuran places polynucleotide (PN), purified from salmonid fish, into the dermis. It is not a filler — it changes the environment the dermis recovers in — and it is a material the body breaks down. That gives it a clear place: skin that has become thin and reactive, and anyone not yet ready for a material that cannot be undone.
What goes in
The active material is polynucleotide (PN) — a long-chain polymer extracted and purified from salmon and trout. Manufacture includes a controlled depurination step, which removes the capacity to carry genetic information.
- It is an aqueous injectable. Liquid from the start — nothing to reconstitute.
- It is not particulate. A single polymer, so there is no structure that can aggregate into something palpable.
- It breaks down. It is gradually degraded, and it changes the environment as it goes.
PN and PDRN are not different materials — they are chain-length ranges of the same material, PDRN the shorter, PN the longer. Where the class sits overall is in collagen boosters compared.
There is more than one formulation
If a consultation ends at “we’ll do Rejuran,” it is worth asking which one. They differ in what they target and in how the treatment feels.
| Formulation | Character | Where we use it |
|---|---|---|
| Healer | PN alone | When texture and dermal density are the goal |
| HB | Hyaluronic acid added, so it shows less immediately after placement | When downtime has to be short |
| HB PLUS | Contains lidocaine; discomfort tends to ease as the session goes on | Sensitive patients · larger areas |
The differences are set out in Rejuran HB versus regular Rejuran; the product itself is on the Rejuran page.
What it targets — stated as a plane
Rejuran targets dermal texture and density. When that plane lifts, skin texture and the way light reflects change.
| Main concern | Direction that fits |
|---|---|
| Thinner skin, coarser texture | Where Rejuran belongs |
| Flushes easily with any stimulus | Where Rejuran belongs — a degradable material is a lighter place to start |
| Lost volume | A filling material — Rejuran does not fill |
| Laxity | RF · ultrasound · threads |
| Pigment or redness | Laser |
Which skin states are candidates is tabled in Rejuran in Daegu: which skin suits it.
When you want room to change your mind
One axis is often skipped when choosing a booster: is this the right material to place right now?
- Rejuran is degraded by the body. What goes in does not stay in place indefinitely.
- So it is a lighter place to start. That is why we offer it first to patients new to boosters, to reactive skin, and to anyone not yet ready for a material that cannot be undone.
- In exchange, it is built up over sessions rather than finished in one.
What becomes visible when
| Point | What you see | What to do |
|---|---|---|
| Same day | Each placement point sits slightly raised (papules) | The face that day is not the result |
| 1–2 days | The papules largely settle | Back to normal activity |
| Around session 2 | Texture and feel change first | Where most people first notice it |
| After the course | The change becomes clear | Compare against the pre-treatment photograph |
Papules are not nodules. They are physical swelling where the material sits in the dermis, a different phenomenon from the aggregation nodules that matter with particulate products. More in Rejuran bumps: why they form.
How we place it
| Plane | Dermis — plane first, then the points |
|---|---|
| Formulation | Chosen from Healer · HB · HB PLUS against pain sensitivity, schedule and area |
| Sessions | Three to four, three to four weeks apart, as one course |
| Maintenance | Decided by the state of the skin, not the calendar — a single top-up when dryness and texture return |
| Said first | That the face on the day is not the result |
Before treatment
- Pregnancy and breastfeeding — we suggest a different time.
- Active infection or inflammation at the site — we wait for it to settle.
- Blood-thinning medication — tell us, but do not stop it on your own. Expect a little more bruising.
- A recent booster elsewhere — we separate them in time, so that any reaction can be attributed.
Afterwards: pain that does not settle, pain worsening on one side only, skin turning white or purple, any change in vision, or swelling with redness, heat and tenderness together — do not count days, contact us.
Frequently asked questions
What is Rejuran made of?
Polynucleotide (PN) extracted and purified from salmon and trout. Manufacture includes a controlled depurination step that removes the capacity to carry genetic information. It is an aqueous injectable, not a particulate one.
What does Rejuran target?
Dermal texture and density. It is not a filling product, so if lost volume is the main concern that is a different material. We separate texture, volume and laxity before naming any product.
How many sessions?
We run three to four sessions, three to four weeks apart, as one course — a degradable material is built up rather than finished in one. After the course we top up by the state of the skin, not the calendar.
Why do the bumps form?
They are physical swelling where the material sits in the dermis, and a different phenomenon from aggregation nodules. They usually settle within a day or two. How pronounced they are varies with formulation and technique, which is why we say first that the face on the day is not the result.
I have never had a booster — is Rejuran a reasonable start?
It is where we usually start. It is degraded by the body, so it is a lighter commitment, and it suits skin that has become thin and reactive. The same reasoning applies if you are not yet ready for a material that cannot be undone.
When will I notice anything?
Most people notice texture and feel around the second session, and the change becomes clear after the course. On the day of treatment the face looks raised because of the papules — that is not the result.
Can it be combined with another booster?
Yes, but separated in time. On the same day, a reaction cannot be attributed to either one. We place one, review the skin, and then decide the combination.
Read next
Who wrote this
Written and reviewed by Lee Chi-Hak, MD, director of Miso Clinic, Daegu. The treatment standards and injection design here are the ones we use in practice.
4F Bombom Building, 125 Dongdeok-ro, Jung-gu, Daegu, Korea (Exit 1, Kyungpook National University Hospital Station)
+82-53-428-2700 · www.clinicmiso.co.kr
This is general medical information and does not replace consultation. Indications, method and whether to treat at all should be decided after examination.
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